Brain 'rust' a cause of Alzheimer's
September 7th 2010 15:17
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Danny Rose, Medical Writer
September 6, 2010
AAP
Australian scientists have made a significant advance in the understanding of Alzheimer's disease, a condition they describe as an accumulation of brain "rust".
An imbalance in the metals needed for healthy brain function has been found at the root of the degenerative disease which afflicts 10 per cent of people aged over 60.
University of Melbourne Professor of Pathology Ashley Bush and his research colleagues have traced the imbalance to the brain's improper and related processing of zinc and iron.
Their research is detailed in a paper to be published in the prestigious international journal Cell later this month.
"The brain in Alzheimer's disease is a catastrophe, and it is very hard to pinpoint what went wrong first," Prof Bush told AAP on Monday.
"This (research) really unravels quite a big series of knots and highlights a particular sequence involving these two metals.
"... It is the most in-depth series of biochemical discoveries about Alzheimer's disease and its causes to date."
The research focused on the complex relationship between amyloid precursor protein (APP) and its breakdown product amyloid, along with the zinc and iron.
Prof Bush said as zinc was seen to accumulate in amyloid it blocked the APP from performing its critical, and previously unknown, job of exporting iron out of the brain's neurons.
This led to a build-up of iron "in the grey matter", he said, resulting in oxidative stresses that could kill off neurons.
So could you say the loss of mental function in an Alzheimer's patient is caused by rust in their brain?
"In a chemical sense, you can," Prof Bush said.
"That's the kind of chemistry that is going on in the brain and, similar to actual rust, it involves an abnormal combustion of oxygen with iron.
"The brain is an unusual organ in that it has very high concentrations of metals which it uses for its electrical chemistry."
While the research does not reveal the complete picture of the cause of Alzheimer's disease, Prof Bush said it had uncovered a vital "corner piece of the jigsaw puzzle".
Revealing more of the factors contributing to Alzheimer's disease hands the scientific community a broader target, as they work to develop treatments that could halt the damage.
Prof Bush is co-founder of the biotechnology firm Prana, which is working on a novel Alzheimer's drug (PBT2) that aims restore normal levels and distribution of metals in the brain.
He said the research strengthened expectations that PBT2, now in clinical trials, would one day be able to reverse brain damage in Alzheimer's patients.
"This information should encourage the powers that be to push ahead with this drug," Prof Bush said, adding research and development would take at least another three years.
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Comment by Spring-Heeled Jack
Over.Exposure
On the other hand, I'm a bit mystified as to why it's taken so long to link oxidisation (ie the 'rusting' of the body over time) with the disease, as it's pretty much the base cause of all things to do with ageing.
Comment by katyzzz
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I don't think man will ever understand the human body well and certainly not entirely, it's a task tougher than climbing Mt. Everest, Everest has a peak, understanding the human body has no peak and can therefore never be reached.
Comment by Spring-Heeled Jack
Over.Exposure
Comment by katyzzz
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