Prenatal Drinking, Environmental Enrichment: Effects On Neurotrophins Are Independent Of Each Other
July 20th 2008 23:01
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ScienceDaily (July 18, 2008) — Prenatal alcohol exposure may be particularly destructive for neurotrophins, a family of peptides that influence the growth, development and functional plasticity of the fetal brain. A new rodent study of alcohol's effects on three key neurotrophins has found that, even though environmental enrichment may be able to improve some fetal-alcohol effects, those benefits do not appear to be mediated by neurotrophins.
"Neurotrophins are produced in the nervous system and are critical for normal development of the brain," explained Robert F. Berman, a professor in the department of neurological surgery and at the Center for Neuroscience at the University of California -- Davis, as well as corresponding author for the study.
"Neurotrophins also play important roles in learning and memory, and contribute to the repair of the brain following injury or stress. We chose to examine three -- nerve growth factor (NGF), neurotrophin-3 (NT-3), and brain-derived neurotrophic factor (BDNF) -- because previous research had shown that prenatal alcohol exposure alters their levels in the brain, and that treatment of other types of brain injury with NGF or BDNF can be beneficial."
Researchers divided 22 pregnant Sprague-Dawley rats into four groups: Zero (receiving 0 g of alcohol), Low (4 g/kg/day), High (6 g/kg/day) and Naïve (untreated pregnant rats). The two alcohol groups were given alcohol on gestational days eight to 20. After weaning on postnatal day 21, the 228 offspring were housed for six weeks in one of three conditions: Isolated, Social or Enriched. Levels of NGF, NT-3 and BDNF were then measured in the offsprings' frontal cortex, occipital cortex, hippocampus, and cerebellar vermis.
"We found that prenatal alcohol exposure generally increased brain neurotrophin levels in adult rats," said Berman. "This suggests that neurotrophin levels increased as compensation for damage to the developing brain from prenatal alcohol exposure. Results also demonstrated that the effects of prenatal alcohol exposure can be enduring and last into adulthood."
Previous rodent research conducted by Berman had shown that rearing rats in an enriched environment following prenatal alcohol exposure improved their motor function as well as learning and memory. "In this study, we found that being raised in an enriched environment, with ample opportunities for motor and sensory stimulation, and social interactions, unexpectedly resulted in reduced levels of neurotrophins in some areas of the cortex, but not in other areas which are well known to be affected by prenatal alcohol exposure," he said.
When both sets of findings are considered together, he added, they indicate that the effects of prenatal alcohol exposure and environmental rearing conditions on neurotrophin levels are largely independent, with little evidence that one directly influenced the other's effects on neurotrophin levels. "In other words," he said, "our results did not support our hypothesis that the beneficial effects of early environmental enrichment in rats exposed prenatally to alcohol were mediated directly by the three neurotrophins we examined in four specific brain areas."
This means that the molecular and cellular mechanisms underlying environmental enrichment effects after prenatal alcohol exposure are still not understood, said Berman. "While the importance of the postnatal rearing environment for brain development is clear, we need additional research to aid in devising rational treatment strategies for Fetal Alcohol Spectrum Disorders, including fetal alcohol syndrome," he said.
So don't DRINK when you are pregnant, there is no safe level of alcohol consumption.
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Comment by Clint Emry
Strategy and Solutions
Have you read Brave New World?
It is very relevant to what your saying here.
Class structure being engineered by introducing alcohol into the child's embryonic environment!
Comment by S.L.
The Political Brief
Comment by TimmyH
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Can you HACK it?
Genyration
Comment by katyzzz
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Comment by katyzzz
Photography Tips
Health Focus
Poetry Lighthouse
MS Paint Art
Comment by katyzzz
Photography Tips
Health Focus
Poetry Lighthouse
MS Paint Art
These things can be difficult to understand but every new bit of knowledge helps and even when I put up info here that is not new, it goes to inform people who have not heard it before.
Not that this article would mean a lot to most people, but it does sound a note of caution, not generally practised.
And yes, I'd like to be able to HACK - do you give lessons?