9 Steps to Reverse Dementia and Memory Loss As You Age
June 27th 2010 23:15
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From: The Huffington Post
Dementia is a big problem and growing every day. Ten percent of 65-year olds, 25 percent of 75-year olds, and 50 percent of 85-year olds will get Alzheimer's disease -- at a cost of $60 billion a year to society. Worse, the number of people with Alzheimer's is predicted to triple in the next few decades. It is now the seventh leading cause of death.(i)
I believe this preventable, that we can slow this trend and even reverse it. In a moment, I will tell you how. But first I want to explain why just naming a disease -- whether it is dementia or anything else -- is becoming increasingly unhelpful (unless you just want to match the drug to the disease which is the only thing doctors are trained to do).
We have to think about individuals, not diseases. In medicine, our genetic differences are more important than our similarities.
Sometimes the practice of medicine lags behind the science, and sometimes the practice gets ahead of the science. Genetic testing puts us squarely in the middle of that dilemma. We are at a crossroads, where the old ideas we have about disease and diagnosis become less meaningful as we understand more and more about the importance of individual differences in determining illness. This a time when personalized medicine will replace medicine based on diagnosis and disease.
In fact, disease and diagnosis as we know it will soon be an obsolete concept, an artifact of medical history, like bloodletting or phrenology (the art of diagnosis based on the shape of your skull, popular in the 19th century). The reason is simply this: Naming a disease does nothing to help us identify and treat the underlying causes of the disease. We must address these causes if we have any hope of helping individuals heal.
Even though no long-term studies have been done to look at treating dementia based on genes, there are so many scientific threads that weave together a picture of how and why our brains age and what genes are involved. This leads me back to George ...
For this man, whose mind and life were evaporating, I looked deeply into his genes and the biochemistry his genes controlled and found places where we could improve things.
He had a gene called apo E4, which is a high-risk gene for Alzheimer's disease(ii) and also made it hard for him to lower his cholesterol and detoxify mercury from his brain.(iii) He also had a version of a gene for detoxification of metals and other toxins (glutathione-S-transferase, or GST)(iv) that was very inefficient, making him accumulate more toxins over his lifetime. Having the combination of a problem with GST and apo E4 puts people at even more risk for dementia.(v),(vi) In another study, people with an absent GST gene were likely to have much higher levels of mercury.(vii)
George had another gene called MTHFR(viii) that made him require very high doses of folate to lower his blood levels of homocysteine, which is a substance very toxic to the brain. Lastly, he had a gene called CETP that caused his cholesterol to be high, which contributes to dementia. Combine this gene with the apo E4 gene and your risk of dementia goes way up.(ix)
We found that George had high levels of mercury(x) and helped him detoxify with foods such as kale, watercress, and cilantro, herbs such as milk thistle, nutrients such as selenium and zinc, and medications that helped him overcome his genetic difficulties by getting rid of toxins.
We lowered his cholesterol with diet and herbs. We lowered his homocysteine with high doses of folate and vitamins B6 and B12.
What happened then was impressive ...
After a year of aggressive therapy that was matched to his genes, not his diagnosis, he had a remarkable and dramatic recovery. Before I saw him, he could not manage his business, nor did his grandchildren want to be around him. After matching his treatment to his genes, he was again able to function, and his grandchildren loved being with him again.
While this area of genetic testing and nutrigenomics is new, and more research is needed to help us refine our understanding and treatment, there are ways to look through new doors into an entirely new era of medicine that no longer focuses on the disease, but on the person and their uniqueness. Here's another example of how we can do that.
A woman named Christine was eighty and was experiencing severe memory loss and cognitive decline. Her family was obviously concerned, so she was tested with hours of neuropsychological testing and found to have dementia.
Her neurologist offered her words of comfort, but told her and her family there is no treatment truly effective to stop or reverse the progression of dementia. That's when her daughter brought her to see me.
We discovered many subtle changes in her health that on their own wouldn't explain dementia, but when added all together put a strain on her brain function. All we did was correct those problems -- low thyroid function, mercury toxicity, inflammation, and deficiencies in vitamins B6 and D, folate, coenzyme Q10, and omega-3 fats -- and improved her diet overall. I encouraged her to exercise, because exercise can help improve cognitive function and prevent dementia.
Six months later, she had the extensive memory tests repeated. Her psychologist was surprised to report that her scores got BETTER!
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